Haemodynamic goal-directed therapy and postoperative infections: earlier is better. A systematic review and meta-analysis - 06.11.2015

Twenty-six RCTs (4188 participants) met the inclusion criteria. Perioperative GDT significantly reduced surgical site infections (SSI) (pooled OR 0.58; 95% CI 0.46-0.74; P<0.0001), pneumonia (pooled OR 0.71; 95% CI 0.55-0.92;P=0.009), and urinary tract infections (UTIs) (pooled OR 0.44; 95% CI 0.22-0.84; P=0.02). A significant benefit on total infectious episodes emerged (OR 0.40; 95% CI 0.28-0.58; P<0.00001).

A flow-directed hemodynamic therapy aimed to optimize oxygen delivery protects surgical patients against postoperative hospital-acquired infections and must be strongly encouraged, particularly in the setting of the high-risk surgical population.

Lidia Dalfino et al. Crit Care 2011; 15:R154

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