November 2015

Relation between mean arterial pressure and renal function in the early phase of shock: a prospective, explorative cohort study. - 06.11.2015

In 217 patients with sustained hypotension, enrolled and followed prospectively, we compared the evolution of the mean arterial pressure (MAP) during the first 24 hours between patients who will show AKI 72 hours after inclusion (AKIh72 as defined as “Injury” or “Failure” classes of the RIFLE classification [using the creatinine and urine output criteria] or […]

Haemodynamic goal-directed therapy and postoperative infections: earlier is better. A systematic review and meta-analysis - 06.11.2015

Twenty-six RCTs (4188 participants) met the inclusion criteria. Perioperative GDT significantly reduced surgical site infections (SSI) (pooled OR 0.58; 95% CI 0.46-0.74; P<0.0001), pneumonia (pooled OR 0.71; 95% CI 0.55-0.92;P=0.009), and urinary tract infections (UTIs) (pooled OR 0.44; 95% CI 0.22-0.84; P=0.02). A significant benefit on total infectious episodes emerged (OR 0.40; 95% CI 0.28-0.58; […]

Prevention of ventilator-associated pneumonia, mortality and all intensive care unit acquired infections by topically applied antimicrobial or antiseptic agents: a meta-analysis of randomized controlled trials in intensive care units - 06.11.2015

Topical selective decontamination of the digestive or respiratory tract (SDRD) using antiseptics or antimicrobial agents is effective in reducing the frequency of VAP in ICU. Unlike antiseptics, the use of topical antibiotics seems to be effective also in preventing all ICU-acquired infections, while the effectiveness on mortality of these two approaches needs to be investigated […]